Sub micron voxel resolution provides images of fine structures in living cellular material that is essential to studies involving GFP labels and other fluorescent protein studies.

Intra-cellular ion waves, calcium puffs and sparks

Fast synchronised image scanning speed coupled with an appropriately sensitive camera and imaging technology provides the capability of capturing fast dynamic events such as calcium sparks.

FRET

Ratioing of emission wavelength images provides an on-line indication of dynamic changes in FRET activity suitable for studies using FRET coupled fluorescent probes. With additional equipment the may also be adapted for studies requiring localised photo-bleaching, for example FRAP, FLIP, etc.

Co-localisation

Capturing pixel on pixel registered multiple wavelength images, either sequentially or simultaneously depending on experiment conditions, records the perfect data for co-localisation studies.
The ability to optically superimpose the confocal images on bright field, phase contrast and other conventional microscope images is also a powerful tool to identify the location of fluorescent sources in the confocal section with respect to the underlying structures, without necessarily having multiple fluorescent stains.

Tissue section morphology, 3D reconstruction

Real time confocal imaging enables the observation and recording of blood circulation in vivo and the study of movements / reactions in micro-organisms. The high degree of confocality provides clear cross-section views of whole mount embryo and pathological or histological specimens.
Fast focus mechanisms enable rapid collection of z-stacks, significantly reducing the 'time-skew' errors inherent in slower systems. The z-stack data is available for subsequent 3D reconstruction and analysis.

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